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TOPIC: Potentiators of Kratom...

Potentiators of Kratom... 1 year 10 months ago #24143

  • madmaxnightrider
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If you are a regular Kratom user, you may sometimes feel that it is just the typical experience.

After the long-term experience with Kratom, most of the users express that the effects sometimes feel less.

There is a dire need of something which is as good as Kratom but higher as per effect like mood lifting effects.

These similar effects are common if the Kratom which a person uses is old.

Storing it for too long may sometimes change the chemical composition, and you may feel it’s not the good old Kratom anymore.

Honestly, there is no alternative of Kratom. Kratom feels so good that no one can revert to chemical alternatives after using it.

There is no way that this problem will have a fix with a substitute. The thing which can fix is to enhance its mood lifting effects.

You may have heard about enhanced Kratom strains which have more alkaloids in them for even more benefits.

It’s a similar thing, only except that a user can practice it safely at home. Also, there is no requirement of any specialized Kratom or alkaloids for it.

Just the regular Kratom and a few enhancing agents will work well. Here is how it can be helpful for you.

You may have heard about enhanced Kratom strains which have more alkaloids in them for even more benefits.

It’s a similar thing, only except that a user can practice it safely at home. Also, there is no requirement of any specialized Kratom or alkaloids for it.

Just the regular Kratom and a few enhancing agents will work well. Here is how it can be helpful for you.

What does enhancing Kratom mean?
Enhancing or Potentiating means to add strength to something. As per Kratom is concerned, enhancing is a chemical technique to make it more stable.

Anyhow, this article is telling you about the home-based, easy way to experience mood lifting effects of Kratom that work efficiently for you.

It involves no industrial process, just simple home based techniques which will work for you.

Nature is amazing; it has a helping system where all elements can help each other. This goes for the plants as well.

As Kratom is a plant, its mood lifting effects can be stronger with certain types of other plants, food elements or even with the systematic methodology.

It is more like a remedy to make Kratom work for you.

How does Kratom potentiators work?
The elements which helpful for making Kratom more powerful follow an easy way to.

The idea behind adding these enhancing agents to Kratom is to make the effect intense but slow so that the user enjoys them.

The higher effects like Mood Lifting is less likely to achieve in small dosages.

The user needs a high dosage to get the mood lifting feelings. It suggests using the enhanced Kratom which makes the effects prolong and high.

The science which favors this effect of Kratom is to slow down the metabolism.

The enzyme cytochrome P450 which is responsible for controlling the alkaloids of Kratom to the blood plays a vital role.

This enzyme is influenced by the particular type of foods.

So the idea is to combine your regular Kratom with specific additional components which help to reduce the activity of enzyme P450.

By this way, the effects will be higher, as the dosage is greater but long-lasting.

How to get intense Kratom Mood Lift effects?
There are multiple ways to enhance Kratom. A careful combination of Kratom with certain food products is very much helpful as per user reviews.

Once you use a higher dose of Kratom with supplementary food, the mood lifting is stronger and lasts longer than the regular Kratom dosage.

Not just the mood lifting, all other effects such as stress relief, pain control, stamina, energy, and concentration improves too.

How to enhance the effects of Kratom?
Following are multiple ways to increase the mood lifting and other higher effects of Kratom.

Boosting Kratom Effects with Natural Foods
By far the easiest and simplest way is to combine Kratom with a food element. It is safer and most convenient of all methods.

Here is a list of top food ingredients with which Kratom works best for mood lifting effects.

Turmeric Powder
Who doesn’t acknowledge the benefits of turmeric? Above all elements, turmeric is the favorite most of users who are common worldwide.

Turmeric is a strong spice which boosts the effects of Kratom. Turmeric Powder easily mixes with Kratom powder, or you can take turmeric powder before taking Kratom. Both ways it works best.

Grape Fruit
One of the most healthy fruits on earth, grapefruit makes a perfect combination with Kratom powder.

It is interesting that many of the Kratom users already prefer to use Kratom powder with fruit juice mainly citrus.

It’s more like a remedy to increase the mood lifting effects of Kratom with grapefruit juice.

This is an excellent combination which is 200% efficient but remembers that grapefruit itself is very reactive.

It may enhance the effect of Kratom but affect the digestive enzymes.

The elements of grapefruit have linkage with metabolism which is why it is a popular choice for weight loss too.

However, this may not be a useful point when Kratom is in it. For Mood Lift, sedation, opiate withdrawal and pain management, this combination is the perfect one.

Cayenne Pepper
Cayenne pepper is a sharp and intense spice which is popular for its role in detox and cleansing the body from inside. It enhances the production of saliva which improves the digestion.

It is a favorite weight loss agent and chronic pain relief. When in combination with Kratom in powder form, both these ingredients complement each other.

Cross check the user sensitivity to the cayenne pepper before mixing it with Kratom.

The addition of cayenne pepper in Kratom will enhance the effectiveness of both.

Cayenne pepper and Kratom are not advisable in equal ratios because of highest potency for each other.

Usually very less, around 1/4th of cayenne pepper can work well as per Kratom’s quantity. It can be increased later on with time.

Black Pepper
Another effective but not as such famous enhancer of Kratom is black pepper. Mixing both these can increase all effects of Kratom by 300%.

However, make sure that you aren’t allergic to black pepper before using it.

Watercress
Watercress is a type of lettuce which can be helpful to use with Kratom. It does improve the effects of Kratom, but that increase is very less as compared to up listed food choices.

Boosting Kratom effects with teas
If you are not a fan of food, tea is always a good alternative. Herbal tea is necessary to follow a healthy lifestyle.

An addition of herbal products like chamomile, green tea, passion flower, etc. will be excellent for your health.

Kratom is an equally useful component to make tea like all rest. It will provide the most soothing effects to the body.

Combine Kratom alone or along with chamomile and green tea for the extra benefits. If a user wants alertness and focus, Kratom can even mix well with coffee.

Boosting Kratom effects with supplements
The third choice to make the regular Kratom more strong is to add supplements. Following are a few good options for this recipe.

Valerian Root: popular as a herbal component, this root has supplements commonly available in the market.
They are mainly used for peaceful sleep and relaxation. Kratom and Valerian root supplement can go well together for the stress release, sedation, and Mood Lift.
Cat’s Claw: Cat’s Claw is another potent supplement which has similar alkaloids as that of Kratom.
When you combine both, the alkaloid amount is more than twice. This leads to more potent effects of Kratom.
Caffeine: Caffeine is an effective component fo tea and coffee. However, you can easily get its supplement from the market.
Taking caffeine supplements with or before Kratom will increase the cognitive function to a higher level.
How to take Kratom with its potentiators?
More than what to combine in Kratom, the problem is how to take it. The enhanced formula will not work well if you are not using it in the right manner.

For example using the Kratom right after food, tea or supplement will not work.

For the best results, consume the additional components 30-45 minutes prior taking Kratom.

Except for tea, which can even have Kratom inside it. This method, however, needs experience and personal preference as well.

Final thoughts on enhancing Kratom mood lifting effects
Mood Lifting is an effect which is only common after higher dosage. It suggests that Kratom has to be high enough to create this effect.

If the user experience with Kratom is static to the same level of results or the Kratom which is in use is old, both way Kratom needs a boost.

This boost can either be a natural eatable or a supplement.

It is safer to use a natural enhancer like tea, juice, spices than chemically modified supplements.

Mood Lifting effects begin to show in 10-15 minutes after taking the dosage. For best results, switch and experiment with enhancing agents.

What do you mean by potentiation aka enhancement of Kratom effects?
Potentiation is a concept in Pharmacology which means that there is an interaction between two substances, either chemical or physical that leads to a response that is pharmacologically greater than the sum of individual response to each substance.

The same phenomenon is applied on Kratom. Certain supplements, herbs, and drinks are taken along with Kratom to improve its effects. This can also be achieved even by concentrating Kratom, in the form of extracts and tinctures. So the next time you hear about an 8x or a 15x extract, know that it’s the form of Kratom that will give you stronger effects as the alkaloids of Kratom have been concentrated.

Why do you require enhancement of Kratom effects?
The Kratom effects enhanced by using various synthetic herbs as well as supplements. It can also help to decrease the amount or dose of Kratom being taken and to ensure that the effects last longer. The addition of natural or synthetic herbs results in increased elimination half-life of Kratom. Thus, the metabolites of Kratom remain in the system and act on the opioid receptors.

People also use this concept to enhance the onset of action. Usually, Kratom starts working within 15-30 minutes, but if potentiated it shows quicker effects within 5-15 minutes. Potentiation also helps in giving stronger effects.

The Kratom stimulation will be more active. The analgesic effect will be heightened.


What drugs potentiate Kratom and what is the mechanism?
To understand the interaction between Kratom and other drugs, we need to have a glance at the metabolic pathway of Kratom.

Basically, Kratom is metabolized in the liver by a set of enzymes called the ‘microsomal enzyme system of the liver.’

These enzymes breakdown Kratom into its metabolites that are ineffective and do not act on the opioid receptors. Thus, they are excreted by the kidneys. The main enzymes involved in the metabolism of Kratom are CYP2D6 and CYP3A4.

Certain drugs like Cimetidine, Dextromethorphan, Diphenhydramine, Phenylephrine, and Acetaminophen are the main inhibitors of this microsomal enzyme system of the liver.

Once they inhibit these enzymes, Kratom is not metabolized, and it stays in its active form. Thus, it acts for a longer duration of time.

Diphenhydramine is responsible for increasing sedation caused by kratom.
Acetaminophen enhances the analgesic effect of Kratom.
Tianeptine increases the mood lift from Kratom.
Agmatine also enhances the effects of Kratom as well as Gabapentin. It helps in potentiating the anxiolytic effect of Kratom.
Though such drugs are great potentiators of Kratom, they are to be avoided. These can develop quick tolerance and cause high dependence.

The adverse effects of these medications in combination with Kratom are higher than the benefits.

If you are suffering from any cardiovascular, renal or hepatic disorders, try to avoid mixing drugs as your clinical condition might get exacerbated.

What are the herbal natural supplements that enhance the Kratom effects?
Natural supplements are the best as they have negligible side effects. They do not affect any organ system of the body.

Some of the natural substances that enhance the effects of Kratom are grapefruit juice, turmeric, Cayenne Pepper, Tea, watercress, etc.

Grapefruit enhances the duration of action of Kratom.
Turmeric activates the alkaloids present in Kratom and it can be taken regularly with Kratom.

Cayenne pepper enhances the elimination half-life of Kratom.
Chamomile and green tea enhance the soothing effect of Kratom and they also improve the energy levels of the user.
Watercress contains minerals that synergize the effects of Kratom.

What other substances can be taken to enhance the effects of Kratom?
Taking coffee with Kratom is a real example of synergism as caffeine found in coffee is a central nervous system stimulant. Valerian root promotes the soothing and calming effects of Kratom and helps in achieving quicker sedation. Other than this Cat’s claw can be taken to reduce the time taken for onset of action and increase the duration of action of Kratom.

While taking any drug in combination with Kratom, ensure that you have full knowledge about the drug interactions and side effects of that drug. Otherwise, you may get into trouble as potentiators may lead to excessive sedation leading to coma, respiratory arrest, and death.

Also, one type of substance shouldn’t be taken regularly. Instead, Kratom should be taken in pure form, and not even in the form of extracts or tinctures.

The reason being that you may develop quick tolerance to it as well as dependence and on quitting you may suffer withdrawal symptoms like that of Opiates.

Also, ensure that if you have an underlying disease, you should avoid all sort of drugs and only take prescribed medicine.
If anybody has any Questions about Kratom please private message me or make a Post & I will be glad to answer as soon as I can usually within 24 hours if not sooner. I'm usually on really late at night Between Midnight & 5am.
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Potentiators of Kratom... 1 year 10 months ago #24201

  • Nickd76
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Thank you very much for this information! This is great and will definitely try each! I appreciate this!
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Potentiators of Kratom... 1 year 10 months ago #24257

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No Problem. Always here to help.
If anybody has any Questions about Kratom please private message me or make a Post & I will be glad to answer as soon as I can usually within 24 hours if not sooner. I'm usually on really late at night Between Midnight & 5am.
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Potentiators of Kratom... 1 year 10 months ago #24418

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I've read several posts that Pircalima Nitida (Akuamma seed or Akuammine seed) is an excellent potentiator, but I haven't tried it yet. Just wondered if anyone can share their experience with this.

"The most abundant and active alkaloids in the Akuamma seeds are effective for pain relief, treatment of malaria, diarrhea, and considered as the best muscle relaxant. The Akuammine and akuammidine are the main alkaloids found in the Akuamma seeds that is structurally related to Mitragynine (the most active alkaloid in the Mitragyna speciosa Kratom plant)".

Thanks! :)
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