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Mscanlan4803 wrote: just to show you ill post a few links to where you can read the studies and claims of why its supported that psuedoindoxyl is stronger.
Recent studies indicate that mitragynine and 7-hydroxymitragynine bind to and partially activate human µ-opioid receptors, the same receptors fully triggered by morphine. Also, it was reported that the compound mitragynine pseudoindoxyl, generated by fermenting mitragynine, is an even more potent activator of µ-opioid receptors than mitragynine and 7-hydroxymitragynine. Mice treated with a typical painkilling dose of mitragynine pseudoindoxyl experienced little respiratory depression, a common side effect of opioids such as morphine. These are early evidence of therapeutic potential for the plant compounds and their derivatives that can be produced semisynthetically.
Initial investigations used in vitro radioligand binding assays with cell lines stably
expressing murine opioid receptors (Figure 2, Table 1). Mitragynine (1) showed poor affinity at
all opioid receptors, whereas 7-hydroxymitragynine (2) showed moderate affinity at the mu
opioid receptor clone MOR-1, 5-fold higher than 1, and was considerably more potent at the
expressed delta opioid receptor clone DOR-1 than 1.
44 Mitragynine pseudoindoxyl (3) displayed
the highest overall binding affinity for MOR-1 and DOR-1 (Ki 0.8 nM and 3 nM, respectively)
while also showing a moderate affinity for KOR-1 . These data suggest that conversion of the
indole to indolenine ring to the spiro-pseudoindoxyl core dramatically increases affinity for
Mscanlan4803 wrote: So i just tried Betuangie for the first time today from a trusted and proven source that truly ferments their kratom. Which is the process of which true Betuangie is created. It is a very euphoric brand of kratom, and at the same time I have energy but no negative side effects. So far this is my favorite kratom. I have read in lab studies that this type of process to which they process Betuangie alters the alkaloids of mitragynine and 7ohm to create another alkaloid called mitragynine psuedoindoxyl. Now i've heard mixed reports on this from kratom enthusiasts that claim this alkaloid is less active in the body blah blah blah. I also read on ncbi through lab study in rats that this alkaloid is far much stronger than the others. It is in close relation and effects to morphine, and in this case shows stronger ability to be analgesic and create euphoria without recruiting b arrestin (which morphine does) which is known to suppress your breathing. Now i have noticed a much greater euphoria and analgesic effect with this type of kratom than compared to any other brand, strain, or origin i've taken so far. What are your thoughts guys, have you taken this before? Do you like it or dislike it? and are there any other kratom strains, names, origins, etc that is your go to or is close to the effects of Betuangie
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